This information sheet explains three natural supplements sometimes used alongside standard care for the management of endometriosis-related pain. These are not replacements for medical or surgical treatments. Always speak with your doctor or pharmacist before starting any new supplement.
Pycnogenol® (French maritime pine bark extract)
Pycnogenol contains natural antioxidants that reduce inflammation and support blood vessel health. Studies have shown improvements in menstrual pain and reduced need for painkillers in some women with endometriosis.
Suggested dose: 60 mg daily (30 mg twice daily) for at least 2–3 months.
Possible side effects: Mild stomach upset or headache; may increase bleeding risk if taken with aspirin or blood thinners.
N-Acetylcysteine (NAC)
NAC is an antioxidant that helps the body produce glutathione. In research, women taking NAC experienced reduced pelvic pain and smaller ovarian endometriomas, with some spontaneous pregnancies reported.
Suggested dose: 600 mg capsule three times a day for 3 consecutive days each week (or 600–1800 mg daily). Continue for 3 months.
Possible side effects: May cause mild nausea or stomach discomfort. Avoid combining with nitroglycerin. Use caution with asthma.
Turmeric (Curcumin)
Curcumin, the active compound in turmeric, has anti-inflammatory effects. While helpful for general period pain, a high-quality study in women with endometriosis did not show major pain relief. Some evidence suggests benefit when combined with hormone therapy.
Suggested dose: 500 mg twice daily of a standardized extract with piperine (for better absorption). Try for 8–12 weeks.
Possible side effects: May cause reflux or indigestion. Avoid in gallbladder disease or with blood thinners.
Monitoring Your Progress
Most women who notice improvement do so within 8–12 weeks. Keep track of your pain and general wellbeing. If symptoms worsen, or if you develop severe pain, fever, or vomiting, contact your doctor immediately.
This information is for general education only and should not replace medical advice. Discuss all supplement use with your gynaecologist, especially during fertility treatment or pregnancy.
